Imagine the shock of your baby being born with a swollen brain, blindness and debilitating seizures. Now imagine learning that these devastating conditions could have been prevented if you took a simple test for the common parasite Toxoplasma gondii.
Toxoplasma can be picked up anywhere an infected cat has defecated, such as the litter box, sandbox, garden or yard. Other routes of infection include consumption of contaminated water, undercooked meat or shellfish. Most people experience mild illness and can get the infection under control.
However, if contracted for the first time while pregnant, Toxoplasma can cross the placenta and cause spontaneous abortion or serious birth abnormalities. Such mother-to-child transmission during pregnancy is called congenital toxoplasmosis. Up to 4,400 babies may be born with congenital toxoplasmosis in the U.S. each year.
As professor of microbiology at the Indiana University School of Medicine, I study the biology of Toxoplasma in my lab. Blood tests can monitor the amount of Toxoplasma antibodies in the parent. Increases indicate an acute infection is taking place, putting the fetus at risk of congenital toxoplasmosis. However, promptly administering anti-parasitic drugs to pregnant people who develop toxoplasmosis can help protect the fetus from the worst outcomes of congenital toxoplasmosis.
Several nations, such as France and Austria, have been testing and treating toxoplasmosis during pregnancy for decades. Brazil recently started a similar program.
However, Toxoplasma testing is not included in prenatal screening in the U.S.
Why screen for toxoplasmosis during pregnancy?
Toxoplasma is a widespread and stealthy infection. Over 40 million American adults are infected with the parasite, underscoring how easy it is to catch. And since the infection usually doesn’t cause overt symptoms, many mothers of infected babies cannot recall when or how they became infected.
Studies conducted in multiple countries have demonstrated the benefits of detecting and treating toxoplasmosis during pregnancy.
The first randomized clinical trial assessing the efficacy and safety of a treatment to reduce toxoplasmosis transmission prenatally, Toxogest, published its findings in 2018. Although the trial was halted due to lack of funding, results suggested that treatment not only reduced infection transmission, but also decreased disease severity for breakthrough infections.
Imagine the shock of your baby being born with a swollen brain, blindness and debilitating seizures. Now imagine learning that these devastating conditions could have been prevented if you took a simple test for the common parasite Toxoplasma gondii.
Toxoplasma can be picked up anywhere an infected cat has defecated, such as the litter box, sandbox, garden or yard. Other routes of infection include consumption of contaminated water, undercooked meat or shellfish. Most people experience mild illness and can get the infection under control.
However, if contracted for the first time while pregnant, Toxoplasma can cross the placenta and cause spontaneous abortion or serious birth abnormalities. Such mother-to-child transmission during pregnancy is called congenital toxoplasmosis. Up to 4,400 babies may be born with congenital toxoplasmosis in the U.S. each year.
As professor of microbiology at the Indiana University School of Medicine, I study the biology of Toxoplasma in my lab. Blood tests can monitor the amount of Toxoplasma antibodies in the parent. Increases indicate an acute infection is taking place, putting the fetus at risk of congenital toxoplasmosis. However, promptly administering anti-parasitic drugs to pregnant people who develop toxoplasmosis can help protect the fetus from the worst outcomes of congenital toxoplasmosis.
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